|
KMID : 0606320020180010007
|
|
Journal of Phamacetical Sciences Sookmyung Women s University
2002 Volume.18 No. 1 p.7 ~ p.14
|
|
|
Effect of 2-[(4- cyanophenyl) amino]-3- chlore-1,4- naphthalenedione (NQ-YIS) on Immunopathology and Humoral Immunity in Mice
|
|
Pyo Myoung-Yun
|
|
|
Abstract
|
|
|
|
In order to investigate the e fffcts of 2- [(4-cyanophenyl)amino] -3-chloro-1,4- naphthalenediode (NQ-Y 15) on immune system in mice, we examined the immunopathological parameters and splenic IsM plaque forming cells (PFC) in this study. The immunopathological parameters (weights of body and organs, hematological parameters) were examined on day 1,2,4 and 6 fe11owing single oral administration of NQ-Y15 (125,250,500 mg/kg) to female ICR mice. The weight of body was not changed. However, the weights of organs were slightly increased, and among hematological parame -ters WBC and platelet (PLT) were slightly changed in a dose- and test day- dependent manner when compared with control group. When NQ-Yl 5 was administered before immunization with SRBC- antigen, PFC was significantly and dose-independently enhanced, but PFC was slightly decreased only at a high dose of NQ-Yl5 when administered after antigenic challenge. These results indicate that the effects of NQ- Yl5 on primary humoral immune response may be dependent on the timing of its administration relative to the initial antigenic challenge.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|